The purpose of this study was to retrospectively investigate cases of death due to carbon monoxide (CO) poisoning in the province of Aydın in western Turkey. The study investigated the cases of death due to CO poisoning that were autopsied at the Adnan Menderes University Department of Forensic Medicine from 2002 to 2012. The mean age of the 33 autopsied cases of fatal CO poisoning was 60.30 ± 4.082 years, and 75.8% of the cases were men. The highest level of CO in blood was 79.7%. It was found that most of the CO poisoning deaths were related to accidents.